Abstract Views :188 |
Authors
Source
NIMHANS Journal, Vol 8, No 1 (1990), Pagination: 57-61
Abstract
The enzymes of glutamate metabolism in gerbil brain were studied were unilateral cerebral ischemia. Following 10 min of ischemia the activities of aspartate and alanine aminotransferases, glutamate dehydrogenase and glutamine synthetase were inhibited significantly while gulatminase activity was increased. Recirculation for 30 min after 10 min of ischemia enhanced the activities of transaminases but decreased the activities of glutamate dehydrogenase and glutamine synthetase. Glutaminase activity was normalized during recirculation. The results suggest that failure of detoxification mechanisms of glutamate in brain during ischemia might be the cause for glutamate neurotoxicity in ischemic brain damage.
Keywords
Cerebral Ischemia, Enzymes, Glutamate Metabolism
